Genomic variants-driven drug repurposing for tuberculosis by utilizing the established bioinformatic-based approachShort communication Published on 2022-12-012022-10-05 Journal: Biochemistry and Biophysics Reports [Category] 신약개발, [키워드] annotations applied approach bioinformatics biological process CCR5 CD44 cellular component contribute CXCR4 demonstrated deregulation disease disease-associated drug Drug discovery Drug repurposing drug target evaluated Evidence facilitate functional functional annotation Genes genomic genomic variant genomic variants GWAS HLA-B identify implementation in-silico indication involved KEGG Missense mutation molecular overlapped Pathogenesis Pathway analysis provided risk SELP suggested target Treatment Tuberculosis variant [DOI] 10.1016/j.bbrep.2022.101334 [Article Type] Short communication
Missense mutations in spike protein of SARS-CoV-2 delta variant contribute to the alteration in viral structure and interaction with hACE2 receptorArticle Published on 2022-09-012022-11-16 Journal: Immunity, Inflammation and Disease [Category] SARS, 변종, 유전자 메커니즘, [키워드] ACE2 ACE2 receptor Acidic acute respiratory syndrome Alter analyzed circulating computational analysis conformational contribute contributed coronavirus coronavirus disease COVID-19 Defense delta variant disease domain elevated Evidence functional hACE2 receptor help Host Immune escape in viral India induce infection rate Interaction L452R mechanism Missense mutation molecular molecular docking Morphological Mutation mutations Pandemics physiochemical analysis Protein provided respiratory tract infection RNA SARS-CoV-2 SARS-CoV-2 delta spike glycoprotein Spike protein spike protein. stability T478K the RBD variant variant spike virus [DOI] 10.1002/iid3.683 PMC 바로가기
COVID-19 related acute necrotizing encephalopathy with extremely high interleukin-6 and RANBP2 mutation in a patient with recently immunized inactivated virus vaccine and no pulmonary involvement최근 면역 불활화 바이러스 백신을 접종하고 폐 침범이 없는 환자에서 매우 높은 인터루킨-6 및 RANBP2 돌연변이를 갖는 COVID-19 관련 급성 괴사성 뇌병증Case Reports Published on 2022-07-232022-09-11 Journal: BMC Infectious Diseases [Category] COVID19(2023년), SARS, 변종, 치료기술, 치료제, [키워드] Acute kidney injury Acute necrotizing encephalopathy ADE affecting alteration Analysis antibody blood pressure blood-brain barrier body temperature bpm Brain caused Celsius characteristic Chest Chest radiograph Clinical course Coma Computerized tomography consciousness COVID-19 COVID-19 vaccine cytokine cytokine signaling Cytokine storm Cytokines delta variant Encephalopathy examination Factor gene analysis heart rate hemorrhage hepatic failure heterozygous Hypothesis IL-6 immune response immunized inactivated Inactivated vaccine incidence of COVID-19 infiltration interleukin-6 lesion minute Missense mutation mitochondrial Mitochondrial function Mutation Necrosis oxygen oxygen saturation Pathogenesis Patient Potential treatment predictor preserved Previous studies Prognostic factor pulmonary disease pulmonary involvement pyelonephritis Ranbp2 RANBP2. reported respiratory respiratory rate role SARS-CoV-2 SARS-CoV2 infection Seizure Septic shock Sequencing Serum IL-6 Sinopharm Stupor Vaccine viral entry virus whole genome Whole genome sequencing [DOI] 10.1186/s12879-022-07610-0 PMC 바로가기 [Article Type] Case Reports
Genome sequence diversity of SARS-CoV-2 obtained from clinical samples in Uzbekistan우즈베키스탄의 임상 샘플에서 얻은 SARS-CoV-2의 게놈 서열 다양성Article Published on 2022-06-272022-09-11 Journal: PLoS ONE [Category] COVID19(2023년), SARS, 변종, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 affected Alpha Amino acid amino acid substitution annotation association change clade clades clinical isolates clinical sample Cluster coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 severity D614G Deleterious Deletion Delta Denmark disease severity evidenced Evolution female followed by genetic diversity Genome Genomic analysis genomic change Genotype help Identified isolate isolates male Missense Missense mutation Missense mutations Mutation Nextstrain NSP Nsp12 nsp13 Nsp3 nsp4 NSP6 nucleotide Open reading frame ORF ORF7a Pathogenesis PCR-positive patient Protein reading regions Research Russia SARS-CoV SARS-CoV-2 SARS-CoV-2 strain SARS-CoV-2 variant SARS-CoV-2 variants sequence severe acute respiratory syndrome Coronavirus severity significantly SNP SNPs subclade Substitution synonymous Tashkent the Spike two group two groups USA variant variants Variation WGS whole genome sequence with COVID-19 [DOI] 10.1371/journal.pone.0270314 PMC 바로가기 [Article Type] Article
Main protease mutants of SARS-CoV-2 variants remain susceptible to nirmatrelvirSARS-CoV-2 변이체의 주요 프로테아제 돌연변이체는 여전히 니르마트렐비르에 감수성입니다Article Published on 2022-04-152022-09-11 Journal: Bioorganic & medicinal chemistry letters [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] anticipated antiviral agent Antiviral agents B.1.1.529 B.1.351 Beta catalytically competent Coronaviral COVID-19 COVID-19 pandemic drug target Effectiveness Efficacy expressed in vitro data inhibitor inhibitors Lambda M pro main protease Missense mutation Multiple multiple mutations mutant Mutation Nirmatrelvir not compromised omicron P.2 PF-07321332 prevalent protease public health threat SARS-CoV-2 SARS-CoV-2 lineage SARS-CoV-2 variant Specific Spike protein susceptible the spike protein Vaccines variant variants variants of SARS-CoV-2 variants. wildtype [DOI] 10.1016/j.bmcl.2022.128629 PMC 바로가기 [Article Type] Article
Whole genome sequence analysis showing unique SARS-CoV-2 lineages of B.1.524 and AU.2 in Malaysia말레이시아에서 B.1.524 및 AU.2의 독특한 SARS-COV-2 계통을 보여주는 전체 게놈 서열 분석Research Article Published on 2022-02-252022-09-10 Journal: PLoS ONE [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] age Analysis analyzed approach association caused characterized China circulating clade country COVID-19 COVID-19 case COVID-19 cases D614G variant D614G variants dispersion dominant lineage Evolution Gender genetic diversity genome sequence GISAID Lineage lineages Malaysia Missense mutation nasopharyngeal NCBI oropharyngeal swab pandemic Phylogenetic analysis positive Prevalence real-time RT-PCR reported responsible RT-PCR SARS-CoV-2 SARS-CoV-2 evolution SARS-CoV-2 genome sequence SARS-CoV-2 genome sequences SARS-CoV-2 isolate SARS-CoV-2 isolates SARS-CoV-2 lineage scarcity selected sequence sequenced spike Spike protein Spread statistical analysis submitted sustained the SARS-CoV-2 the spike protein transmembrane domain unique virus WGS [DOI] 10.1371/journal.pone.0263678 PMC 바로가기 [Article Type] Research Article
High diversity in Delta variant across countries revealed by genome‐wide analysis of SARS‐CoV‐2 beyond the Spike protein스파이크 단백질을 넘어 SARS-CoV-2의 게놈 전체 분석에 의해 밝혀진 국가 간 Delta 변이체의 높은 다양성Article Published on 2022-02-142022-09-10 Journal: Molecular Systems Biology [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료법, [키워드] Alpha Alpha variant Amino acid Analysis Beta Bioinformatics analysis contagious coronavirus country Delta delta variant dominant feature focus genomes highlight identify life list Microbiology, Virology & Host Pathogen Interaction Missense mutation Mutation mutations neutralization nucleocapsid other variant other variants pathogenic performed Prevalence prevalent prevalent strain Protein Proteins proteome public health reduced SARS‐CoV‐2 SARS‐CoV‐2 genome SARS‐CoV‐2 genomes SARS‐CoV‐2 protein SARS‐CoV‐2 proteins SARS‐CoV‐2 spike Spike protein susceptibility systematic analysis the Spike Transmissibility Vaccines Viral viral loads while [DOI] 10.15252/msb.202110673 PMC 바로가기 [Article Type] Article
Molecular dynamic simulation analysis of SARS-CoV-2 spike mutations and evaluation of ACE2 from pets and wild animals for infection riskSARS-CoV-2 스파이크 돌연변이의 분자 역학 시뮬레이션 분석 및 감염 위험에 대한 애완 동물 및 야생 동물의 ACE2 평가Article Published on 2022-02-012022-09-11 Journal: Computational biology and chemistry [Category] COVID19(2023년), SARS, 변종, [키워드] ACE2 ACE2 receptor ACE2 receptor recognition Analysis animal Animal host binding binding ability binding affinity caused contagious coronavirus disease Coronavirus disease 2019 Course COVID-19 Critical glycoprotein health emergency Host human ACE2 humans infection risk interact Interaction intermediate host life Missense mutation Missense mutations modeling mole molecular dynamics molecular dynamics simulations Molecular modeling Mus mutant Mutation mutations PALM Pandemics pangolin question RBD RBD region Receptor-binding domain reported SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 sequence SARS-CoV-2 sequences SARS-CoV-2 spike SARS-CoV-2 spike protein SARS-CoV-2 spike protein. SARS-CoV-2 transmission spike gene spike glycoprotein Spike mutant Spike protein Stress susceptibility the binding affinity the RBD the receptor-binding domain the SARS-CoV-2 the spike protein transmission of SARS-CoV-2 transmitted viral spike virus vole wild animal wild animals [DOI] 10.1016/j.compbiolchem.2021.107613 PMC 바로가기 [Article Type] Article
A Rare STXBP2 Mutation in Severe COVID-19 and Secondary Cytokine Storm SyndromeArticle Published on 2022-01-202022-10-29 Journal: International Review of Cell and Molecular Biology [Category] COVID-19, [키워드] accompanied Activation approach Blood caused CD107a CD8 T cell Cell clinical feature Coronavirus disease 2019 COVID-19 cytokine levels Cytokine storm Cytokine storm syndrome cytolysis cytotoxicity death degranulation disease dominant-negative elevated erythroleukemia etiologies Ex vivo expression feature gene mutations genetic defect genetic evaluation genetic mutations genetics hemophagocytic lymphohistiocytosis heterozygous HLH homozygous hyperinflammation hypomorphic Hypothesis immune response immune system implicated implication in vitro infancy Laboratory lentiviral macrophage activation syndrome Missense mutation monoallelic mutant Mutation natural killer natural killer cell NK cell NK cell function resulting secondary Severe case severe COVID-19 sHLH significantly stimulated storm STXBP2 syndrome system failure target cell transduced triggered viral infection were measured while wild-type [DOI] 10.3390/life12020149 PMC 바로가기 [Article Type] Article
Variant analysis of SARS-CoV-2 strains with phylogenetic analysis and the Coronavirus Antiviral and Resistance Database계통발생학적 분석과 코로나바이러스 항바이러스 및 내성 데이터베이스를 사용한 SARS-CoV-2 균주의 변이체 분석Research Article Published on 2022-01-112022-09-10 Journal: Journal of Comparative Effectiveness Research [Category] COVID19(2023년), MERS, SARS, 변종, 치료제, [키워드] (alpha Alpha analyses Analysis analysis appear B.1.1.7 B.1.351 B.1.525 B.1.526 B.1.617 bioinformatics coronavirus COVID-19 COVID-19 case Illumina material Missense mutation Missense mutations Next-generation sequencing Phylogenetic phylogenetic analyses Phylogenetic analysis processed reported resistance SARS-CoV-2 SARS-CoV-2 lineage SARS-CoV-2 strain SARS-CoV-2 variants SARS-CoV-2 variation SARS-CoV-2 variations Stanford University strain Strains Surveillance Turkey variant Variation were used [DOI] 10.2217/cer-2021-0208 PMC 바로가기 [Article Type] Research Article